glp-1 drugs and menopause Postmenopausal women on the medication tirzepatide (Zepbound) for obesity lost more weight if they were also using hormone therapy, a retrospective cohort study indicated. https://www.medpagetoday.com/endocrinology/menopause/119594 Can GLP-1 Weight Loss Drugs

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While glucagon traditionally raises blood glucose, the concurrent GLP-1 and GIP agonism counterbalances this hyperglycemic effect, allowing retatrutide to achieve net glycemic improvement while harnessing glucagon's catabolic benefits for energy expenditure and liver fat clearance

Chan School of Public Health in Boston, and colleagues estimated the risk for nonlive birth, abnormal fetal growth, and MCM with GLP-1 RA dispensing in early pregnancy in an observational cohort of pregnant women aged 16 to 55 years with a GLP-1 RA dispensation in the 90 days before the last menstrual period (LMP)

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The role of kinetic context in apparent biased agonism at GPCRs