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To evaluate the cardiovascular outcomes of glucagonlike peptide1 receptor agonists (GLP1RA) in patients with type 2 diabetes (T2DM) and chronic kidney disease (CKD)

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Large analysis finds no significant link between GLP-1 receptor agonist exposure and major birth defects, though urinary malformation risk needs further study.

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Additionally, GLP-1 agonists improve metabolic functions by increasing the production of short-chain fatty acids like butyrate, propionate, and acetate, which serve as energy sources for colonocytes, modulate immune responses, and enhance the production of gut hormones that regulate appetite and glucose homeostasis