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With Saba GLP-1, I noticed I wasnt constantly thinking about food anymore

A new systematic review (Cureus, 2025) examined 15 randomized clinical trials of microbiome-targeted therapiesprobiotics, prebiotics, synbiotics, fecal microbiota transplantation, and fiber-rich dietsin adults with obesity, type 2 diabetes, and metabolic syndrome

Timing and lifestyle factors Heart rate naturally fluctuates throughout the day, and certain factors can amplify the effects of retatrutide on cardiac rate: Caffeine is an adenosine receptor antagonist that independently increases heart rate
[12] [14] For women aged 50 or over with new IBS-type symptoms, ovarian cancer should be considered and CA125 testing may be arranged

Gastrointestinal Issues GI side effects are the most common, especially early on: Nausea Vomiting Diarrhea Constipation These may lessen over time but can persist in some patients, leading to dehydration and nutritional deficiencies
