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Participants were excluded if they met any of the following criteria: (1) age 5 pounds after initiating GLP-1RA experienced a TSH decrease of 0.360.55 mIU/L [29], and similar associations have been reported after bariatric surgery [25, 27, 67]

Think of them as the high-maintenance cousins of the pharmaceutical world

Many patients find that once they've lost weight and achieved metabolic improvements on a direct-pay platform, they reassess whether insurance coverage remains a priority, having already experienced the clinical benefits of prompt, uninterrupted treatment

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Maintenance Dosing: Once the desired therapeutic effect is achieved, a maintenance dose is established

The risk of MACE was reduced by 12% (HR 0.88, 95% CI 0.840.94) with GLP-1RAs and by 11% (HR 0.89, 95% CI 0.830.96) with SGLT2is compared with that in placebo groups, suggesting that GLP-1RAs and SGLT2is reduce the risk of MACE to a similar extent