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Serious but rare risks requiring immediate medical attention (call 999 or go to A&E if severe) include: Severe, persistent abdominal pain (potential pancreatitis) Signs of gallbladder problems (pain in upper right abdomen, fever, yellowing of skin or eyes) Chest pain, severe palpitations, or shortness of breath Severe mood changes or psychotic symptoms (more commonly associated with stimulants) Signs of severe dehydration or acute kidney injury Patients with pre-existing conditions require particular caution, including those with cardiovascular disease, history of pancreatitis, gallbladder disease, eating disorders, psychiatric conditions, or substance use history

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Why It Matters: The results highlight the steep efficacy and safety expectations in the oral GLP-1 marketdominated by Novo Nordisks semaglutide and Eli Lillys orforglipron, both showing double-digit weight reductions

By week 8 to 12, youll likely start noticing weight loss

Over time, lower intakes of essential vitamins and minerals may affect everything from bone health and muscle function to energy levels, making a thoughtful, nutrient-focused approach increasingly important

Yet, its not a new concept