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Absolute risks were estimated based on the calculated RR and mean event rate across control groups for each outcome, and the event rates derived from different treatment durations for each outcome were converted into annual incidences

However, despite the consistency of these findings, several methodological limitations and sources of bias warrant consideration

Unlike injectable GLP-1 therapies such as semaglutide (Ozempic/Wegovy) or tirzepatide (Mounjaro), orforglipron is a daily oral medication

2 GLP-1 RAs, such as semaglutide, also show potential anti-inflammatory properties

Wool's Solution: Clear education about realistic timelines, expected outcomes, necessary lifestyle changes and long-term maintenance requirements

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