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et al (2015) "A Randomized, Controlled Trial of 3.0 mg of Liraglutide in Weight Management" New England Journal of Medicine, 373(1) 3

Sources of uncertainty originate from the panoply of glycemic targets, the complexity of drug therapy, the choice of the first drug, the ideal sequence of drugs after the first drug failure, the possible harms of anti-hyperglycemic drugs, the outcomes of treatment (surrogate versus clinical) and the hierarchy of risk factors to treat for preventing the vascular complications

There is also a current clinical study examining injectable semaglutides effect on coronary atherosclerosis development [27]

Secondly, due to the nature of the database and inherent weakness within the electronic health record study design, we were not able to account for the duration of therapy or compliance with treatment

GLP-1 is also produced by pancreatic islet cells and neurons within the NTS of the brainstem.56 The peptide is rapidly degraded by dipeptidyl peptidase-4 into GLP-1 amide and subsequently cleared renally, resulting in a short half-life of approximately two minutes.47 Activation of the G protein-coupled GLP-1 receptor increases intracellular calcium concentrations within pancreatic islets, thereby promoting insulin exocytosis

Weekly injectables (semaglutide, dulaglutide) require one injection per week