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Robert Kushner, professor of medicine and medical education at Northwestern University, Feinberg School of Medicine, Chicago

Its synergistic triple-agonist mechanism distinguishes it from older incretin-based therapies and makes it a focus of research into advanced obesity and metabolic treatments

They work by mimicking the hormone glucagon-like peptide-1, which regulates appetite and food intake by acting on areas of the brain that control hunger, whilst also slowing gastric emptying

The significant weight reduction seen with these medications has made them valuable tools in managing obesity-related complications, as reflected in NICE guidance and technology appraisals for their use in both diabetes (NG28) and weight management

Q: Will I regain weight if I stop taking these medications

One of the well-established peptide stapling strategies that overcome these limitations involves the use of unnatural amino acids, specifically through hydrocarbon stapling