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12 The substitution of GLP-1 Thr 13 or GIP Ile 7 with Ala obviously decreased their receptor-activating activities 25,26 and the substitution of GIP Ile 7 with Thr decreased its cAMP activity (pEC 50 : 9.769.58;Emax: 9.918.90)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 152.Yamanaka M., Shirai M., Shiina H., Tanaka Y., Tsujimura A., Matsumiya K., Okuyama A., Dahiya R

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The system never gets a meaningful break from stimulation

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