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2023;6(6) doi: 10.1001/jamanetworkopen.2023.17886
The majority of these follow-on patents were filed between 2021 and 2022, coinciding with the launches of Mounjaro and Zepbound (Figure 10)
Research indicates that the activation of GLP-1R can alter the polarization of microglia, shifting them from a proinflammatory (M1) phenotype to an anti-inflammatory (M2) phenotype (Qian et al., 2022)

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Nevertheless, this potential bias can be assessed by conducting sensitivity analyses based on the duration of GLP-1 receptor agonism
