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In Canada, Sandoz (in partnership with Pharmathen) is gearing up for a biosimilar semaglutide rollout post-patent expiry

ACCORD Study Group, Chew EY, Ambrosius WT, et al

The SURMOUNT-5 trial, published in The New England Journal of Medicine in May 2025, is the first large randomized study to compare tirzepatide and semaglutide directly in adults with obesity

We were unable to block the GLP-1-elicited increase in heart rate using sympathetic blockers, an HCN channel blocker, cervical vagotomy, and ganglionic blockade

These hormones work together to regulate your appetite, slow down how quickly your stomach empties, and help your body manage blood sugar more effectively

Clinical trial participants describe feeling satisfied with smaller portions and experiencing reduced food preoccupation, allowing them to focus on other aspects of life rather than constantly battling food urges