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GLP-1 and its analogs exhibit bloodbrain barrier penetrance, enabling direct modulation of central nervous system function 68

One possible explanation is that medications reduce appetite and calorie intake without requiring people to practice the day-to-day behaviors that support long-term maintenance

* Treated with once daily or twice daily basal insulin (Neutral Protamine Hagedorn insulin, insulin degludec, insulin detemir, insulin glargine 100 units/mL, or insulin glargine 300 units/mL): greater than or equal to 90 days prior to the day of screening with or without any of the following anti-diabetic drugs/regimens with stable doses greater than or equal to 90 days prior to screening: * Metformin * Sulfonylureas * Meglitinides (glinides) * DPP-4 inhibitors * SGLT2 inhi Interventional (clinical trial) 526 Randomized Parallel Assignment Not provided Open label Not provided Treatment NCT04795531 Phase III Completed Novo Nordisk A/S This study compares insulin icodec (a new insulin taken once a week) to insulin degludec (an insulin taken once daily which is already available on the market) in people with type 2 diabetes

Patients with prior GERD, reflux-like symptoms, or related conditions were excluded to reduce bias, according to study results published in Annals of Internal Medicine

5B) could be an interference of GLP-1RA treatment with the interdigestive migrating motor complex (MMC), particularly phase 3 of this complex, which is composed of pressure waves often originating in the stomach and propagated segment by segment toward the duodenum and jejunum (108), which is thought to clear the remnants of the preceding meal including indigestible gastric content from the stomach (108, 109)