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Diabetes mellitus is a metabolic disorder with persistent hyperglycemia caused by a variety of underlying factors

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Here we investigate this problem in the nematode gonad, where germline stem cells are maintained by Notch signaling from the niche and PUF RNA binding proteins in stem cells

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This comprehensive review critically evaluates recent advances in BBRs anti-obesity pharmacology through three lenses: (1) preclinical and clinical evidence from randomized controlled trials, (2) molecular mechanisms underlying metabolic regulation, and (3) innovative strategies for pharmacokinetic optimization