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This positive impact on the brains dopamine system could help regulate appetite and contribute to weight loss

In one study, 6-weeks long administration of GLP-1 to type 2 diabetic patients reduced fasting blood glucose and hemoglobin A1c, a measure of long-term sugar control (15)

By explicitly identifying what should not be attempted, the framework reduces the risk of repeating historical failures

In rodents and humans, there is a progressive decrease in circulating GLP-1 across pregnancy [18,19] which, as with insulin resistance that occurs during pregnancy, would cause increased food intake, decreased glucose storage and facilitate shunting of glucose to the growing fetus

Although not examined in this study, the effects may be due to the metabolism of DHEAS into a GABA A receptor agonist in vivo , such as androstanediol or androsterone [143]

Ethics statement Ethical approval was not required for the studies involving humans because of the nature and design (observational case series)