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Phase 3 results had begun appearing, but full regulatory review had not been completed

The conformation of 4-OHT with the maximal free energy binding was selected

Although preliminary findings indicate that GLP-1Ra causes modest BMD reduction and enhances bone remodeling, favoring resorption similar to the effects of calorie restriction, further research is needed

10.1016/j.ejphar.2022.174843 118 SusiniS.RocheE.PrentkiM.SchlegelW

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However, studies with ad libitum eating in both groups tend to favor time-restricted eating, suggesting the eating window itself reduces intake naturally