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Compared with diet-induced obese models (23, 36, 37), Bbs5 / mice exhibited distinct metabolic and immune characteristics, including rapid weight gain, pronounced immune dysregulation, and accelerated deterioration of glucose homeostasis and pancreatic function

Allulose can be used in beverages, baking, or as a tabletop sweetener, though its properties differ slightly from sucrose in cooking applications

The authors suggested that the 37-amino acid peptide homologous in fish and hamster would serve a biologic function

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This is supported by previous findings that ablation of Arx in neonatal cells results in an -to-like conversion through an intermediate bihormonal state, while ablation of Arx in adult mice does not (83)