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Ouyang, Advances in Research on Type 2 Diabetes Mellitus Targets and Therapeutic Agents, Int

Over time, data from secondary and exploratory objectives of large randomized controlled-trials suggested that GLP1-RAs could also exert renal action by slowing the progression of kidney disease in patients with and without diabetes

Current Regulatory Context: The FDA issued a determination that the semaglutide injection product shortage is resolved (decision memorandum dated February 21, 2025)

doi:10.1111/bcp.15816 186

Tirzepatide is a glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist approved for type 2 diabetes management and chronic weight management

Recommendations emphasized risk stratification of individual patients and weighing the risks vs the benefits of holding or continuing GLP-1 and GLP-1/GIP combination receptor agonist medications