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This knowledge informs whether continuous therapy is essential or whether structured maintenance protocols might suffice

A precision stratification approach would enroll participants according to baseline HbA1c strata, degree of insulin resistance, adiposity, systemic inflammatory burden, background medication class, and verified curcumin plasma concentration, substantially improving the interpretability and translational relevance of trial outcomes

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The transition from normoglycemia to prediabetes, and the reverse, were assessed as exploratory outcomes