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Effect of Metformin on Global Gene Expression in Liver of KKAy Mice

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If the injection has been given into muscle (intramuscular) rather than subcutaneous tissue, patients may experience more discomfort at the injection site, potentially faster absorption, and possibly more pronounced side effects

Supporting this notion, MS interactomic analyses of GLP-1R co-immunoprecipitates in INS-1 832/3 SNAP/FLAG-hGLP-1R cells after a 5-minute stimulation with the endogenous agonist GLP-1, as well as with the exendin-4-based biased GLP-1RAs exendin-F1 and exendin-D3, previously shown to trigger differing degrees of GLP-1R internalisation 18,19 , resulted in marked differences in the propensity of the receptor to associate with VAPB (Supplementary Fig