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The meta-analysis identified a nonsignificant increase of 2.4 bpm (95% CI 0.24, 5.05) with GLP-1RA treatment relative to placebo

Most patients notice appetite reduction within the first two weeks of starting GLP-1 therapy, though measurable weight loss typically becomes apparent after 4-6 weeks as consistent calorie reduction accumulates

N.MathieuC.MingroneG.et al (2018)

Available from: Simonsen E, Lund LC, Ernst MT, Hjellvik V, Hamann S

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Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have multiple glycaemic and nonglycaemic benefits in patients with type 2 diabetes, including reduced glycaemia, mortality, cardiovascular events and weight