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For instance, people who experience accelerated aging of the heart face a 250% increased risk of developing heart failure

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Additionally, alterations in Ca 2+ regulation, including leaky ryanodine receptors (RyR2), were ameliorated via the recovery of Na + /Ca2 + exchanger currents

253 GLP-1 secretion from L-cells increases substantially in response to many cytokines such as interleukin-6, and interestingly, GLP-1 levels are elevated in patients with sepsis and are correlated with the severity of illness and clinical outcomes, although it is currently unclear if the elevation of GLP-1 levels exacerbates or alleviates pathology during sepsis

Available case reports demonstrate plausibility, but large observational studies are needed to estimate actual risk