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Side Effects of Tirzepatide and Semaglutide These medications arent silent passengersthey come with a few bumps along the way, especially during the first few weeks or when your dose increases: nausea: a rolling, unsettled stomach that may show up right after meals or linger all day vomiting: especially after overeating or with certain foods bloating: a tight, uncomfortable feeling in your midsection gas: often unexpected and frequent constipation: hard stools or fewer bowel movements than usual diarrhea: loose or urgent stools, sometimes alternating with constipation loss of appetite: you forget to eat, or food just doesnt appeal anymore fatigue: a general sense of low energy or sluggishness, especially early on burping or acid reflux: a burning sensation or repeated belching after meals mild headache: usually short-lived and manageable with rest or hydration injection-site soreness, redness, swelling, or itching: typically mild and short-lived These symptoms often peak during dose escalation and tend to ease as your body adjusts

Rapid improvement in glycaemic control has been associated with temporary worsening of diabetic retinopathy

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This insight allows your PlexusDx clinician to customize your dose escalation schedulesometimes using a slower ramp-upto maximize comfort while reaching your therapeutic dose

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For example, a 2025 patent from Novartis describes linking a cyclic peptide that targets a receptor implicated in cancer to a cancer-killing radionuclide or cytotoxic drug