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This confirmed the glucagon receptor as the primary driver of the direct cardiac effects

Lilly 2026 How Retatrutide Compares to Tirzepatide and Semaglutide Head-to-head network meta-analysis data shows retatrutide produces greater absolute and percentage weight loss than tirzepatide: a mean difference of 16.34 kg absolute weight reduction and 23.77% percentage weight loss versus tirzepatide's 16.79%