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Treatment discontinuation rates due to adverse events were higher in the orforglipron groups compared to placebo, but remained within expected ranges for GLP-1 receptor agonists

The widespread distribution of GLP-1 receptors means these medications can affect multiple organ systems simultaneously

During those extra hours, your stomach is essentially working overtime, churning acid against food that is not moving

However one should not prematurely conclude that bariatric surgery is the better long term strategy for weight loss in every patient

Salamun et al

Tirzepatide was only approved for weight loss two and a half years ago, so there just [hasnt been enough time] to see an effect for a disease like cancer