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Although the risk of NAION to patients should be acknowledged, based on the totality of the evidence evaluating this risk, the authors would not recommend a change in how GLP-1RAs are currently prescribed.

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FDA Commissioner Marty Makary stated in the announcement: "When FDA-approved drugs are available, outsourcing facilities cannot lawfully compound using bulk drug substances unless there is a clear clinical need." The public comment period closes June 29, 2026, after which the FDA will issue a final determination