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Pancreatitis: Seek immediate attention for severe, persistent abdominal pain radiating to the back Gallbladder issues: Rapid weight loss increases gallstone risk
In a phase 2 clinical trial involving 338 adults with obesity, the highest administered dose (12 mg) resulted in an average weight reduction of 24.2% over 48 weeks

Gorabi, A

Postprandial hyperglycemia/hyperlipidemia (postprandial dysmetabolism) is a cardiovascular risk factor

If retatrutide is authorised, wed expect criteria similar to current NHS policies for weight-management injections: a BMI threshold (with lower thresholds for some ethnic groups), presence of weight-related conditions (e.g., hypertension, OSA, prediabetes), and use alongside structured lifestyle support
