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The combination of phentermine and topiramate, under the brand name Qsymia, got the green light for chronic weight management in 2012
[DOI] [PMC free article] [PubMed] [Google Scholar] 293.Touvier M., da Costa Louzada M.L., Mozaffarian D., Baker P., Juul F., Srour B

There is a relative lack of prospective or randomised clinical studies in cohorts of PDM on specific interventions, such as advanced strategies to optimise enzyme replacement therapy, emerging insulin delivery systems or dual incretin agonists

Clin Chem Lab Med 44: 13791382
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