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This has the potential to unlock new, first-in-class treatments for patients with AUD

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In addition, the vagus nerve is a major constituent of a neural reflex mechanismthe inflammatory reflexthat controls innate immune responses and inflammation during pathogen invasion and tissue injury

Probably, it is the result of translocation of bacterial components, particularly LPS, into the portal vein and thus to the liver, resulting in liver inflammation and injury [47]

Journal Reference Simonsen E., Lund L.C., Ernst M.T., Hjellvik V., Hegeds L., Hamann S., Jrstad .K., Gulseth H.L., Karlstad ., Pottegrd A

In humans, Berberine positively impacts obesity by modulating gut microbiota diversity at doses as low as 500 mg/day and significantly improving cholesterol metabolism at 300 mg/day