efficacy of glp 1 receptor agonists Frontiers The predicted impact of GLP‐1

This distal tubular condition is perceived as a low effective circulating volume stimulus, at the level of juxtaglomerular apparatus, which promotes the inhibition of adenosine production that is associated with a vasodilatory response of the afferent arteriole (33)

Novo already sells an oral semaglutide for type 2 diabetes, Rybelsus

Research suggests it might be more effective than medications that target only GLP-1

An extremely strong MCAS reaction in a second patient with long COVID and vaccine syndrome (plus antiphospholipid syndrome and major clot risk factors) caused her body to swell up so much that she had trouble eating

PMID: 36462999 Contreras C et al (2017): Traveling from the hypothalamus to the adipose tissue: The thermogenic pathway

Patients also stop because of cost, loss of insurance, or side effects