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It's worth noting that when GLP-1 receptor agonists are used alongside insulin or sulfonylureas, there is an increased risk of hypoglycaemia, and dose adjustments of these medications may be required

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These medications appear to dial down activity in the brain's reward pathways, the same circuits that make alcohol feel rewarding

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Orforglipron (Foundayo) approved April 2026, the first once-daily GLP-1 pill with no food or water restrictions

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