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This study identifies CCDC3 as a key regulator of MAFLD progression, showing that targeting the CCDC3AGXTglycine metabolic axis can reduce #LiverInflammation, #fibrosis, and #MetabolicDysfunction, opening new avenues for therapy

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C onstitutional symptoms (fever, arthralgias, weight loss, malaise/fatigue) O bstruction Interfering with blood outflow, arrhythmias, interference with valves causing regurgitation, pericardial effusion +/- tamponade (presyncope, syncope, dyspnea, chest discomfort) D istal embolization (pulmonary or systemic thromboembolic phenomenon) When a metastatic tumor is present, distinguishing symptoms originating from the heart becomes challenging due to potential overlap with symptoms caused by the primary malignancy

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10.1016/j.obpill.2024.100138

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Our assessment will review this area to support evidence based decision making by the Minister for Health and the Health Service Executive

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