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Efficacy and safety of GLP-1 receptor agonists in patients with type 2 diabetes and cardiovascular risk: A systematic review

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Similarly, it has been reported that sustained hyperleptinemia in individuals with obesity correlates with increased SOCS3 expression, a negative regulator of leptin signaling, further impairing JAK2-STAT3 activation and reinforcing resistance (7)

Science 330 , 13901393 (2010)

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