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Identification of GIP and GLP-1 as gastrointestinal insulinotropic hormones In 1902, Ernest Bayliss and William Starling identified a substance that is produced in and secreted from the epithelial cells of the duodenum in response to the contact of these cells with acidic chyme [55]

Some patients may experience temporary sleep disruption during periods of active weight loss, though evidence for this specific to tirzepatide is limited

The lack of a relationship between energy intake and changes in gastric emptying and intragastric distribution in individuals treated with lixisenatide is consistent with the concept that effects on appetite are primarily centrally mediated (27)

Lixisenatide reduces amyloid plaques, neurofibrillary tangles and neuroinflammation in an APP/PS1/tau mouse model of alzheimers disease

Secondary outcomes included each of these events considered separately

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