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The trial, called SELECT, was conducted in 41 countries with more than 17,000 people who were overweight or obese and at high cardiovascular risk but who didnt have diabetes

This year, Lilly has been releasing the results of clinical studies finding that orforglipron is safe and efficacious in patients with obesity or type 2 diabetes

Mean TTR decreased by 2.1% (95% CI, -3.7% to -0.6%

10.26355/eurrev_202107_26395 79 LopezL

The mechanism involves glucose-dependent insulin secretion, meaning insulin release occurs primarily when blood glucose levels are elevated, thereby reducing the risk of hypoglycemia when used as monotherapy
Diabetes also is associated with more rapid progression of Parkinsons symptoms in people who have both diseases