glp-1 agonist drugs oral receptor agonists are generating a great deal of excitement as a potential inflection point in diabetes and obesity care. Amid the enthusiasm, however, a quieter and clinically important issue is Oral GLP-1 Medication Helps Patients
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Cell 185 , 11301142.e1111 (2022)
Lancet (London, England)
PubMed Central, Eser, Hale Yapici, et al
Cardiomyocyte/cardiac fibroblast dysfunction is related to abnormal proliferation, apoptosis, hypertrophy, as well as inflammation and fibrosis, which may be caused by mitochondrial dysfunction and metabolic disorders
Furthermore, noted that GLP-1RAs can increase cholesterol excretion and reduce cholesterol accumulation by promoting the expression of ATP-binding cassette transporter A1 (ABCA1) in the endothelium
