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However, in a subsequent cohort of diabetic patients treated for 5 weeks with liraglutide, activation of the OFC in response to food cues was increased, despite successful weight loss, improved metabolic profile, and reduced fat intake [36]

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M., The New WeightLoss Drugs, Lorcaserin and PhentermineTopiramate: Slim Pickings?, JAMA Internal Medicine 174 (2014): 615619

Comprehensive ePRO Portfolio: We have experience in supporting a wide range of ePRO measures to assess aspects of health important to patients with these diseases including: Health-related quality of life (HRQoL, e.g., SF-36, Impact of Weight on Quality of Life-Lite (IWQoL-Lite)(EQ-5D-5L), Food craving (e.g., Control of Eating Questionnaire (CoEQ)), Mental health (e.g., Columbia-Suicide Severity Rating Scale (C-SSRS), Patient Health Questionnaire-9 (PHQ-9)) and other measures such as the Patient Global Impression of Severity/Change (PCIS/C)

Here we show that chronic stimulation of the GLP-1R increases glycolysis and ATP production in -cells through transcriptional activation and expression of glycolytic genes