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However, they can be more expensive and may have gastrointestinal side effects

Dysfunction in these systems leads to the accumulation of misfolded proteins and cellular debris, contributing to neuronal death [95,96]

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Call your health care provider if you have any of the following symptoms: pain in your upper stomach (abdomen), fever, yellowing of your skin or eyes (jaundice), or clay-colored stools increased risk of low blood sugar (hypoglycemia) in adults with type 2 diabetes who also take medicines to treat type 2 diabetes such as sulfonylureas or insulin risk of low blood sugar (hypoglycemia) in children who are 12 years of age and older without type 2 diabetes Signs and symptoms of low blood sugar may include: shakiness, sweating, headache, drowsiness, weakness, dizziness, confusion, irritability, hunger, fast heartbeat, and feeling jittery

however, when these analyses are feasible, this approach would mitigate some of the biases inherent in a pre-/post-study design

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