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Hu SY, Zhang Y, Zhu PJ, Zhou H, Chen YD

Studies have shown that bitter-tasting pharmaceuticals and substances, including polyphenols such as isosinensetin, bind to bitter taste receptors, and unlike other TAS2R agonists, stimulate GLP-1 secretion in NCI-H716 cells [192] (Fig

Meaning there is no standardized regulation on its potency or formulation

Pathways implicated in addiction also contribute to pathological overeating and obesity, they write
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