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Male Mc4r- KO mice were kept on a HFHS diet for 9 weeks and the mice were 17 weeks old at study start (The Jackson Laboratory, 032518)

Body weight is the one covariate that meaningfully moves semaglutide exposure, and it moves it inversely: a lighter body sees more drug per milligram

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You should discuss libido changes with your doctor if you experience new or worsening decreased sexual desire that persists for more than 2-4 weeks, particularly if it affects your quality of life or relationships

It is best to follow a balanced diet to get adequate amounts rather than to change your diet drastically