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Additionally, topiramate can increase heart rate, which may be concerning for some individuals already sensitive to semaglutide's cardiovascular effects

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Brello users report results consistent with this data, including losses of 60 pounds in 6 months and 50 pounds in 4 months
Dual GIP Action The second receptor (GIP) amplifies the metabolic effects but can worsen GI sensitivity early on

Sikiric P, et al