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Abstract The development of glucagon-like peptide 1 (GLP1) receptor agonists, including semaglutide and tirzepatide, has transformed the clinical management of overweight and obesity

However, if cost or insurance coverage is a concern, tirzepatide could be a viable option

Amino acids such as tryptophan, tyrosine, and phenylalanine are particularly susceptible to photochemical reactions that alter their structure and potentially compromise the peptide's ability to activate GLP-1, GIP, and glucagon receptors

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But research on the nasal delivery format specifically remains an open question