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The anorexigenic peptide glucagon-like peptide-1 (GLP-1) is secreted from gut enteroendocrine cells and brain preproglucagon (PPG) neurons, which respectively define the peripheral and central GLP-1 systems

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Marketed under names such as Ozempic, Wegovy, and Rybelsus, Semaglutide works by mimicking a natural hormone that regulates appetite, insulin secretion, and glucose metabolism