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Both native and cloned receptors signal through the activation of both adenylyl cyclase and phospholipase C (76, 129)

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As an example, while the aforementioned evidence suggests that overactivation of the endocannabinoid system may have negative consequences, activation of cannabinoid receptors expressed by pancreatic -cells can stimulate insulin secretion and, therefore, may be beneficial in treating impaired glucose tolerance and diabetes mellitus 61,62

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This investigation followed a complaint from a nonprofit physicians group