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There are many potential/partial explanations for this difference: Tirzepatide is a dual agonist (for GIP/GLP-1), making it an arguably more structurally complex molecule and less tenable for recombinant expression (though both are linear peptides with a side chain)

The pancreas, gut, liver and epididymal adipose tissue were also dissected

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Yu X, Tang H, Huang L, Yang Y, Tian B, and Yu C

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