glp-1 receptor agonist blood pressure reduction Frontiers GLP-1 Agonists in Cardiovascular Diseases:

doi: 10.1007/S12630-023-02440-3 109 FezzaRRainsBFezzaTFezzaJP

Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 19802017: a systematic analysis for the global burden of disease study 2017

GLP-1s inhibition of glucagon secretion appears to be indirectly triggered via paracrine effects in the islets

Semaglutide is a selective GLP-1 receptor agonist

In the isolated perfused porcine ileum, GLP-1 secretion is inhibited by electrical nerve stimulation or by administration of norepinephrine, effects that can be blocked by co-infusion of the nonselective -adrenergic receptor antagonist phentolamine [337]

GLP-1R was further detected in the arterial walls of the kidney and lung, in heart myocytes of the sinoatrial node, and in the Brunner's gland of the duodenum [392]