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The bigger picture Weight management is no longer viewed as a lifestyle issue alone its increasingly recognised as achronic medical conditionrequiring long-term treatment strategies

Baseline blood tests to confirm eligibility

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Its primary outcomes measure is time to first occurrence of any component event of a composite endpoint comprising all-cause death, non-fatal myocardial infarction, non-fatal stroke, coronary revascularization, or heart failure events that result in hospitalization or urgent hospital visits

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AMP-activated protein kinase (AMPK) is an evolutionarily conserved serine/threonine kinase whose activation elicits insulin-sensitizing effects, making it an ideal therapeutic target for T2D