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As a long-acting agent, semaglutide reduces energy intake by decreasing appetite and increasing satiety by direct activation of the hypothalamus and hindbrain and indirect activation via the vagus nerve

2023 Apr;83(5):403-427

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10.1007/s10787-022-00956-6 Inflammopharmacology 4 Aviles-OlmosI.DicksonJ.KefalopoulouZ.DjamshidianA.EllP.SoderlundT.et al (2013)

The heart rate is faster than normal, but the heart beats properly