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Case reports and observational data have noted reductions in thyroid volume and TSH levels in obese individuals treated with GLP-1RAs though the clinical significance is unclear [29]

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In one clinical trial published in The New England Journal of Medicine in 2016, patients with obesity and type 2 diabetes lost an average of 10.8 pounds and lowered their A1C (a measurement of average blood sugar levels) by 1.4 percent after taking 1 mg of semaglutide for 104 weeks (8)

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