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Some of these include: Gastroparesis Ileus Bile duct cancer Gallbladder diseases Gallbladder cancer Vision problems Because so many people have filed lawsuits against Novo Nordisk for adverse effects from taking Ozempic and other GLP-1 receptor agonist medications, these lawsuits have been combined into a multidistrict litigation (MDL)

Diabetic retinopathy For people with diabetes and existing diabetic retinopathy, rapid improvements in blood sugar control can sometimes temporarily worsen the retinopathy

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The GLP-1 medication may be reduced or discontinued while HRT continues at the same dose

Common Causes of Peptide Impurities Solid-phase peptide synthesis errors Incomplete deprotection reactions Amino acid racemization Aggregation and degradation Regulatory guidelines usually require identification of impurities present at 0.10% relative abundance in peptide drug substances