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A framework for assessing inter-individual variability in pharmacokinetics using virtual human populations and integrating general knowledge of physical chemistry, biology, anatomy, physiology and genetics: a tale of bottom-up vs top-down recognition of covariates

Katz, MD, of the John A

Some patients may experience nausea or mild gastrointestinal discomfort, which typically resolves over time

While body weight and composition can influence drug distribution, the half-life of these specific medications is not significantly altered by body weight

2024;326:F301F312

[DOI] [PubMed] [Google Scholar] 767.Korner M., Stockli M., Waser B., Reubi J.C